Inflamed vs. non-inflamed tumors

기본적으로 종양은 inflamed와 non-inflamed로 구분됨.
1. inflamed (preexisting antitumor immune response)
  • TIL high
  • IFN-gamma producing CD8+ T cells
  • PD-L1 in tumor-infiltrating immune cells.
  • possible genome instability (high mutational burden)

2. non-inflamed

  • TIL low 
  • PD-L1 (-)
  • 예) 소아암이 single gene mutation driver에 의해서 driven되는 noninflamed tuor의 대표적인 예임.

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