Total neoadj. therapy (TNT) for locally advanced rectal cancer (JAMA Oncol 2018)
Methods - Retrospective study @MSKCC (2009-2015) - N = 811 with LARC (T3/4 or N+) 320 standard tx. (preop. CRT + postop. chemo) 308 TNT (preop. chemo & CRT) Results TNT group received more planned chemo dose TNT group better in CR rate (36% vs. 21%) Longer F/U results waited. https://jamanetwork.com/journals/jamaoncology/article-abstract/2675916?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert&utm_term=mostread&utm_content=olf-widget_03262018&redirect=true